KIR2DL5B HEK293
CBP74616
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| I. Background | |
| KIR2DL5B是由KIR2DL5B基因编码的一种抑制性杀伤细胞免疫球蛋白样受体,主要表达于自然杀伤(NK)细胞和部分T细胞表面。其胞内区含有两个ITIM(免疫受体酪氨酸抑制基序),在与HLA-C类分子等配体结合后可传递抑制性信号,负向调控NK细胞的杀伤活性。KIR2DL5B是KIR2DL5基因的两种功能性产物之一(另一种为KIR2DL5A),在人群中呈现多态性分布。 | |
| II. Description | |
| KIR2DL5B HEK293细胞,在 HEK293细胞的基础上,稳定表达KIR2DL5B 。 | |
| III. Introduction | |
| Expressed gene: | KIR2DL5B |
| Host Cell: | HEK293 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
Figure 1. Recombinant KIR2DL5B HEK293 constitutively expressing KIR2DL5B. |
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